APPLICATIONS & SOLUTIONS
A growing and ageing population is driving demand for improved healthcare. The genomics revolution has enabled precision diagnoses and personalized therapies. Advances in cell and gene therapy are transforming the way we treat and cure certain diseases. With these developments come fresh challenges, and the need to maintain exceedingly high levels of quality and reliability. Increasingly, constraints on reimbursement globally are driving pharmaceutical manufacturers to place a renewed focus on cost and efficiency.
At Jacobi, we are committed to providing our customers with a reliable source of high-quality ion exchange and activated carbon products for use in their medicines. We supply products used as active or formulation ingredients in human and veterinary medicines, as well as a full line of activated carbon and adsorbent products used in pharmaceutical product manufacturing. With our extensive applications knowledge, Jacobi not only supplies product but also expertise and know-how to ensure our client’s success.
SUMMARY
- Recovery of antibiotics from fermentation broth
- Enzyme immobilization
- Nutraceuticals recovery from plant extracts
- Polyphenols extraction
- Treatment of hyperkalemia
- Vaccines processing
- Antibiotic Removal Devices (ARDs)
- Pharmaceuticals extraction
APIs
A delicate balance of potassium in the body is required for the heart and other muscles to work properly. Hyperkalaemia occurs when the body’s ability to excrete potassium in the renal system is compromised. The use of IEX resins to treat high levels of potassium is a well-established therapy. As a cation exchange resin passes through the GI tract, it exchanges sodium for potassium ions, lowering the patient’s potassium levels.
- Jacobi offers a special grade of dry, powder SAC resin to pharma companies as an API for hyperkalaemia
Bioprocessing
Bioprocessing covers the isolation and purification of drugs as well as nutraceuticals. Modern medicines such as insulins as well as other therapeutic peptides, proteins, and oligonucleotides, rely heavily on the use of chromatography resins to obtain high levels of purity in the manufacturing processes. In addition, the cost-effective isolation and purification of large-scale antibiotics, vitamins, and plant metabolites such as polyphenols relies on the use of adsorbent resins.
- Jacobi’s full line of adsorbent resins and activated carbon products are used to capture, concentrate, and purify large-scale pharmaceuticals, nutraceuticals, and additives.
PHARMA: PROCESSES
Extraction of Amino Acids
Recovery/extraction of aminoacids after fermentation and filtration processes (e.g. L-Lysine). Pharma and food additives.
Demineralisation of Industrial Water
Removal of all ions from a water stream (salts and minerals) to lower conductivity.
Softening
Removal of total hardness (calcium and magnesium) from liquids.
PHARMA: PRODUCTS
Strong Acidic Cation
Strong acidic cation resins are bead sized co-polymers (mainly polystyrene-divinylbenzene) with a sulfuric group which attracts cations. Resinex SAC comes in gel or macroporous types and are available in several bead sizes to adapt to different applications.
Strong Based Anion
Strong base anion resins are bead sized co-polymers (mainly polystyrene-divinylbenzene) with a tertiary or quaternary ammonium group which removes anions in various processes. Resinex SBA comes in gel or macroporous type and is available in different bead sizes.
Weak Based Anion
Weak base anion resins are bead sized co-polymers (mainly polystyrene-divinylbenzene) with tertiary ammonium groups, which are usually macroporous in structure.
Mixed Bed Resins
Mixed bed resins are composed of strong cationic and anionic ion exchangers based on a polystyrene-divinylbenzene matrix that are usually sold in the ready to use (active) ionic forms.
Inert Resins
These are non-functionalized inert media made from Polypropylene or Polyethylene to protect tank nozzles or act as layers in packed beds and mechanical filters.
W A C
WAC are polyacrylic, gel or macro ion exchange beads. They have the unique carboxylic acid functions.
AD Resins
Jacobi’s full line of specialty ion exchange resins for water softening, chelation, and heavy metals removal.
PH Resins
Non-functionalized inert media made from Polypropylene or Polyethylene.
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